Metabolism and Human T Cell Proliferation

The relationship between T-cell metabolism and T cell effector function is little studied for human T cells. A recent publication by K. Renner et al. now reports about investigations of the group with human CD4 and CD8 T cells.

The authors used the CASY, to accurately and reliably determine the cell number and cell volume in proliferation assays and metabolic restriction experiments.

Read the publication here:

Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Kathrin Renner, Anna-Lena Geiselhöringer, Matthias Fante, Christina Bruss, Stephanie Dyer, Gabriele Saeed hammer, Katrin Peter, Katrin singer, Reinhard Andreesen, Petra Hoffmann, Peter Abubakar, Wolfgang Mr, Marina Kreutz.

Eur J Immunol. 2015 Sep;45(9):2504-16. two: 10.1002/eji.201545473

Read in a new white paper how the authors use CASY, to examine the influence of metabolic conditions in the environment of tumors and for monitoring the stimulation of T cells.